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Updated: Apr 12, 2026

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
Published on: February 4, 2018
Lyme carditis
Matthew L Robinson1, Takaaki Kobayashi2, Yvonne Higgins2
1Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, 1830 East Monument Street, Room 448, Baltimore, MD 21287, USA.
Insights
Lyme carditis is a rare heart complication of Lyme disease, often presenting as heart block. Early diagnosis and antibiotic treatment lead to complete recovery for most patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Epidemiology
Background:
- Lyme disease is a tick-borne illness with diverse clinical manifestations.
- Cardiac involvement, known as Lyme carditis, is an uncommon but serious complication.
- Diagnosis can be challenging due to the rarity and subtle early symptoms.
Purpose of the Study:
- To highlight the importance of suspecting Lyme carditis in endemic areas.
- To describe the typical presentation and management of Lyme carditis.
- To emphasize the favorable prognosis with timely treatment.
Main Methods:
- Review of clinical presentations of Lyme carditis.
- Analysis of diagnostic challenges and common cardiac manifestations.
- Evaluation of treatment outcomes with antibiotic therapy.
Main Results:
- Atrioventricular block is the most frequent cardiac finding in Lyme carditis.
- Myopericarditis can also occur in a subset of patients.
- High index of suspicion is crucial for patients with cardiovascular symptoms in endemic regions.
Conclusions:
- Lyme carditis requires a high index of suspicion, especially in patients with heart block from endemic areas.
- Prompt antibiotic therapy and supportive care ensure excellent recovery rates.
- Early recognition and management are key to preventing severe cardiac complications.
Abstract:
Lyme disease is a common disease that uncommonly affects the heart. Because of the rarity of this diagnosis and the frequent absence of other concurrent clinical manifestations of early Lyme disease, consideration of Lyme carditis demands a high level of suspicion when patients in endemic areas come to attention with cardiovascular symptoms and evidence of higher-order heart block. A majority of cases manifest as atrioventricular block. A minority of Lyme carditis cases are associated with myopericarditis. Like other manifestations of Lyme disease, carditis can readily be managed with antibiotic therapy and supportive care measures, such that affected patients almost always completely recover.
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