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Correction

    Circulation Research
    |May 23, 2015
    PubMed

    Insights

    A correction clarifies that c-kit positive progenitor cells primarily generate endothelial cells, with some smooth muscle cells and fibroblasts, and rare cardiomyocytes in murine models. This addresses discrepancies in cell origin research.

    Area of Science:

    • Cardiovascular Research
    • Cell Biology
    • Stem Cell Science

    Context:

    • Previous research on c-kit positive progenitor cells in cardiac tissue reported varying cell differentiation outcomes.
    • Discrepancies existed regarding the specific cell types originating from these progenitor cells.
    • A review article aimed to reconcile these apparently conflicting findings.

    Purpose:

    • To correct a misstatement in a review article regarding the cell types derived from c-kit positive progenitor cells.
    • To accurately reflect the findings of van Berlo et al. (2014) concerning the differentiation potential of these cardiac progenitor cells.
    • To provide a revised understanding of cardiac cell regeneration paradigms.

    Summary:

    • The review article has been corrected to accurately state that van Berlo et al. (2014) observed large numbers of endothelial cells, some smooth muscle cells and fibroblasts, and rare cardiomyocytes originating from c-kit positive progenitors in their murine model.
    • This correction addresses an earlier inaccurate representation of the study's findings.
    • The online version of the article has been updated to reflect this correction.

    Impact:

    • Ensures accurate scientific reporting and understanding of cardiac progenitor cell differentiation.
    • Facilitates clearer interpretation of research on cardiac regeneration and repair.
    • Contributes to a more robust "String Theory" of cardiac cell origins, reconciling previous discrepancies.

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