Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Should reference beam data be used for beam modeling during linear accelerator commissioning?

Medical physics·2026
Same author

Effects of Bicarbonate Ions in Tea Brewing Water on Sensory Properties and Substances of Different Teas.

Foods (Basel, Switzerland)·2026
Same author

Protonated Defect-Engineered Carbon Nitride Enables Bio-Interface-Enhanced Photodynamic Antibacterial Activity with Potential Periodontal Application.

Materials (Basel, Switzerland)·2026
Same author

Kinetics of Transient Tissue Transparency via Refractive Index Engineering (T3RIE) for In Vivo Optical Imaging.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Monte Carlo modeling and phantom studies show Cherenkov emission per unit dose during total skin electron therapy is a function of tissue optical properties.

Medical physics·2026
Same author

3D Reactive Oxygen Species Dosimetry in Pleural Photodynamic Therapy: Integration of Macroscopic Kinetic Modeling and Deformable Registration.

Antioxidants (Basel, Switzerland)·2026

Related Experiment Video

Updated: Apr 12, 2026

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
11:45

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

Published on: May 26, 2015

10.4K

Characterization of tissue optical properties for prostate PDT using interstitial diffuse optical tomography.

Xing Liang1, Ken Kang-Hsin Wang1, Timothy C Zhu1

  • 1Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, USA 19104.

Proceedings of Spie--The International Society for Optical Engineering
|May 23, 2015
PubMed
Summary

Interstitial diffuse optical tomography (iDOT) accurately mapped optical properties in prostate tissue, crucial for effective photodynamic therapy (PDT) and cancer treatment. This method enhances understanding of light distribution for improved clinical outcomes.

Keywords:
Photodynamic therapydiffuse optical tomographyoptical property

More Related Videos

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

13.0K
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

9.4K

Related Experiment Videos

Last Updated: Apr 12, 2026

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
11:45

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

Published on: May 26, 2015

10.4K
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

13.0K
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

9.4K

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Photodynamic Therapy Research

Background:

  • Photodynamic therapy (PDT) efficacy for localized diseases like prostate cancer depends critically on light distribution.
  • Tissue optical properties (heterogeneity) dictate light distribution during PDT.
  • Accurate characterization of tissue optical properties is essential for optimizing PDT.

Purpose of the Study:

  • To characterize optical properties within prostate tissues using an interstitial diffuse optical tomography (iDOT) method.
  • To reconstruct absorption and reduced scattering coefficients by solving the inverse problem.
  • To validate the iDOT method using a prostate phantom with known optical anomalies.

Main Methods:

  • Employed an interstitial diffuse optical tomography (iDOT) approach.
  • Utilized a modified NIRFAST code based on diffusion equation and an adjoint model.
  • Modeled linear sources and investigated crosstalk between optical properties; explored constrained optical property methods.

Main Results:

  • Successfully reconstructed spatial distributions of absorption and reduced scattering coefficients in the prostate phantom.
  • Demonstrated minimal crosstalk effects between absorption and reduced scattering coefficients.
  • Verified the iDOT method's accuracy by comparing reconstructed properties with known values in the phantom.

Conclusions:

  • The iDOT method, using modified NIRFAST, is effective for characterizing prostate tissue optical properties.
  • Accurate reconstruction of optical property distributions is achievable, aiding PDT treatment planning.
  • This technique provides a foundation for improving light dosimetry in prostate PDT.