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Transcriptional control of mitosis: deregulation and cancer

Somsubhra Nath1, Dishari Ghatak1, Pijush Das1

  • 1Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology , Kolkata , India.

Frontiers in Endocrinology
|May 23, 2015
PubMed

Insights

Mitotic regulation ensures proper cell division. Transcriptional deregulation of mitotic proteins, rather than mutations, drives aneuploidy and cancer development.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Mitosis is a fundamental cellular process crucial for cell division.
  • Aneuploidy, an abnormal chromosome number, is linked to cancer development.
  • Cell cycle proteins regulate mitosis, and their dysregulation contributes to aneuploidy.

Purpose of the Study:

  • To review the biology of transcriptional control in mitosis.
  • To evaluate the role of transcriptional deregulation in aneuploidy and tumorigenesis.

Main Methods:

  • Literature review of molecular functioning of mitosis.
  • Analysis of cell cycle specific proteins and their regulation.
  • Investigation of post-transcriptional mechanisms controlling mitotic protein levels.

Main Results:

  • Mitotic protein abundance is critical for timely mitosis.
  • Aberrant expression of mitotic proteins is observed in various cancer types.
  • Transcriptional deregulation is the primary cause of altered mitotic regulator expression in tumors, not mutations.

Conclusions:

  • Transcriptional control of mitosis is a key factor in tumorigenesis.
  • Understanding transcriptional deregulation is vital for cancer research.
  • Targeting transcriptional pathways may offer new cancer therapeutic strategies.
Keywords:
aneuploidycancermitosismutationtranscription

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