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Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
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Isavuconazole: a new extended spectrum triazole for invasive mold diseases

Michelle R Ananda-Rajah1, Dimitrios Kontoyiannis

  • 11Infectious Diseases Unit, Alfred Health, Melbourne, VIC, Australia.

Future Microbiology
|May 23, 2015
PubMed

Insights

Isavuconazole offers effective treatment for invasive fungal infections like aspergillosis and mucormycosis. This broad-spectrum antifungal agent demonstrates improved tolerability and pharmacokinetics compared to voriconazole.

Area of Science:

  • Mycology
  • Pharmacology
  • Infectious Diseases

Background:

  • Invasive fungal infections pose significant mortality risks.
  • Broad-spectrum antifungal agents are crucial for treatment.
  • Isavuconazole represents a novel triazole prodrug.

Purpose of the Study:

  • To evaluate the efficacy and safety of isavuconazole.
  • To compare isavuconazole with voriconazole.
  • To assess isavuconazole's pharmacokinetic profile.

Main Methods:

  • Open-label, non-comparative study for initial efficacy assessment.
  • Randomized, double-blind clinical trial comparing isavuconazole to voriconazole.
  • Pharmacokinetic and safety analyses.

Main Results:

  • Isavuconazole showed efficacy in treating various fungal infections, including mucormycosis.
  • Fewer adverse events and discontinuations were observed with isavuconazole versus voriconazole.
  • Isavuconazole exhibits favorable pharmacokinetics, including excellent oral bioavailability and once-daily dosing.

Conclusions:

  • Isavuconazole is a promising broad-spectrum antifungal with a favorable safety and tolerability profile.
  • Its pharmacokinetic properties support therapeutic streamlining.
  • Clinical efficacy supports its use in invasive fungal diseases.
Keywords:
invasive aspergillosisinvasive fungal infectionsisavuconazolemucormycosis

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