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Detection of microRNA SNPs with ultrahigh specificity by using reduced graphene oxide-assisted rolling circle
Xiaoli Zhu1, Yalan Shen, Jiepei Cao
1Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
Chemical Communications (Cambridge, England)
|May 23, 2015
Abstract:
Here we report a reduced graphene oxide-assisted rolling circle amplification for the detection of miRNA SNPs. The difference of the signal of a miRNA SNP reaches 100 fold, a value over 10 times larger than some current methodologies, which allows the discrimination of a SNP even with the naked eye.
