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Updated: Apr 12, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Telemedicine framework using case-based reasoning with evidences.
A Sene1, B Kamsu-Foguem2, P Rumeau3
1Laboratoire Génie de Production (LGP), EA 1905, ENIT-INPT, Université de Toulouse, 47 avenue d'Azereix, BP 1629, 65016 Tarbes Cedex, France; Laboratoire de Gérontechnologie La Grave, CHU Toulouse/Gérontopôle/UMR 1027 Inserm-Université Toulouse 3, Hôpital La Grave, Place Lange, TSA 60033, 31059 Toulouse Cedex 9, France.
This study introduces a telemedicine framework using knowledge engineering and ontology modeling to enhance medical decision-making and traceability. The approach integrates evidence-based knowledge into case-based reasoning for improved healthcare delivery.
Area of Science:
- Medical Informatics
- Artificial Intelligence in Healthcare
- Knowledge Engineering
Background:
- Telemedicine facilitates remote healthcare delivery through electronic information exchange.
- Effective telemedicine requires robust information management and traceability for clinical applications.
- Integrating evidence-based knowledge is crucial for enhancing medical decision-making processes.
Purpose of the Study:
- To present a novel telemedicine framework incorporating knowledge engineering and ontology modeling.
- To improve the accuracy and traceability of medical decision-making in telemedicine.
- To enhance the integration of evidence-based knowledge within case-based reasoning for healthcare.
Main Methods:
- Developed a telemedicine framework utilizing knowledge engineering, ontology modeling, and semantic similarity.
- Enhanced a five-step case-based reasoning process (diagnosis, retrieve treatment, apply evidence, adaptation, retain) with an explicit evidence application step.
- Employed natural language processing, ontology, and indexing for information processing and case representation.
Main Results:
- The proposed framework effectively models patient information and treatments using medical ontologies.
- Demonstrated the framework's utility in oncology, highlighting the role of evidence and expert opinions.
- The enhanced case-based reasoning process improves traceability and supports evidence-based medical decision-making.
Conclusions:
- The developed telemedicine framework offers a robust approach for medical decision support and application deployment.
- Integrating evidence-based knowledge and expert opinions enhances the effectiveness and safety of telemedicine care.
- This research contributes to advancing telemedicine by improving information management and reasoning processes.
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