Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

4.4K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
4.4K
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

2.7K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.7K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.6K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.6K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.9K
Dysrhythmias I: Introduction01:15

Dysrhythmias I: Introduction

795
Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
795
Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

487
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
487

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bicontinuous Interconnected Porous Biomaterials for Tissue Engineering and Regeneration.

Small science·2025
Same author

Pluripotent stem cell-derived extracellular vesicles for systemic immune modulation in diabetes therapy.

Research square·2025
Same author

Direct oral anticoagulants versus warfarin in adult heart transplant recipients.

JHLT open·2025
Same author

Single-Cell Atlas of the Tricuspid Valve Unveils the Matrifibrocyte-Driven Fibrotic Landscape in Functional Tricuspid Regurgitation.

JACC. Asia·2025
Same author

Global Multidisciplinary Cardiometabolic Care Delivery: A Blueprint for Success From UNITE.

JACC. Case reports·2024
Same author

Exploring Cardiac Fibrosis: A Novel Ex Vivo Model Using Whole Mouse Hearts.

JACC. Basic to translational science·2024

Related Experiment Video

Updated: Apr 12, 2026

Intramyocardial Cell Delivery: Observations in Murine Hearts
08:12

Intramyocardial Cell Delivery: Observations in Murine Hearts

Published on: January 24, 2014

14.2K

Arrhythmia in stem cell transplantation.

Shone O Almeida1, Rhys J Skelton2, Sasikanth Adigopula1

  • 1Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 100 UCLA Medical Plaza, Suite 630 East, Los Angeles, CA 90095, USA.

Cardiac Electrophysiology Clinics
|May 24, 2015
PubMed
Summary

Cardiac cell therapy shows promise, but delivery methods can cause arrhythmias. This review discusses the risks of cell transplantation in the heart, focusing on delivery techniques and graft properties that may lead to irregular heartbeats.

Keywords:
ArrhythmiaCardiomyocyteCouplingElectromechanicalParacrineRegenerationStem cell

More Related Videos

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment
08:24

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

Published on: May 25, 2020

7.6K
Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

5.1K

Related Experiment Videos

Last Updated: Apr 12, 2026

Intramyocardial Cell Delivery: Observations in Murine Hearts
08:12

Intramyocardial Cell Delivery: Observations in Murine Hearts

Published on: January 24, 2014

14.2K
Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment
08:24

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

Published on: May 25, 2020

7.6K
Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

5.1K

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Biomedical Engineering

Background:

  • Stem cell therapies offer potential for treating diverse diseases.
  • Clinical translation of cardiac cell therapy faces significant technical hurdles.
  • Current cell delivery methods can impact cardiac function and safety.

Purpose of the Study:

  • To review the arrhythmogenic potential of cell delivery methods for cardiac regenerative therapies.
  • To identify factors contributing to arrhythmias after cardiac cell transplantation.
  • To inform safer clinical application of cardiac cell-based treatments.

Main Methods:

  • Literature review of preclinical and clinical studies on cardiac cell therapy.
  • Analysis of cell delivery techniques and their association with arrhythmias.
  • Discussion of electrophysiological properties of transplanted cells and their interaction with host tissue.

Main Results:

  • Intramyocardial injection is associated with an increased risk of arrhythmias.
  • Heterogeneity in conduction velocity between graft and host can promote reentrant pathways.
  • Graft automaticity is another potential cause of cardiac rhythm disturbances.

Conclusions:

  • Technical challenges in cell delivery remain a barrier to widespread cardiac cell therapy.
  • Understanding and mitigating arrhythmogenic risks are crucial for advancing cardiac regenerative medicine.
  • Further research is needed to optimize cell delivery strategies for cardiac repair without inducing arrhythmias.