Related Experiment Video

Updated: Apr 12, 2026

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

2.3K

Everolimus induced Pneumonitis

Q Badar1, N Masood2, A N Abbasi1

  • 1Dept of Radiation Oncology, Aga Khan University and Hospital, Karachi, Pakistan.

The Gulf Journal of Oncology
|May 25, 2015
PubMed

Insights

Everolimus, an mTOR inhibitor, can cause rare pneumonitis in patients with metastatic renal cell carcinoma. Early recognition and drug discontinuation are key for patient safety and recovery.

Area of Science:

  • Oncology
  • Pharmacology
  • Pulmonology

Background:

  • Everolimus (RAD 001) is an oral mTOR inhibitor used in organ transplantation and advanced renal cell carcinoma (RCC).
  • Noninfectious pneumonitis is a rare adverse reaction associated with mTOR inhibitors like everolimus.
  • Prompt identification and management of this toxicity are crucial for patient safety.

Purpose of the Study:

  • To report a case of everolimus-induced pneumonitis in a patient with metastatic renal cell carcinoma (mRCC).
  • To highlight the importance of recognizing and managing this rare adverse event.

Main Methods:

  • Case report of a 72-year-old male patient with mRCC.
  • Observation of adverse events following 4 months of everolimus treatment.

Main Results:

  • The patient developed pneumonitis after 4 months of everolimus therapy.
  • Everolimus was discontinued, and the patient received appropriate treatment.
  • The patient was discharged after 10 days of hospitalization, indicating successful management.

Conclusions:

  • Everolimus-induced pneumonitis is a rare but significant toxicity.
  • Vigilance and prompt intervention are essential for managing this adverse reaction in mRCC patients.
  • Effective management can lead to patient recovery.

More Related Videos

Refined Murine Model of Idiopathic Pulmonary Fibrosis07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

1.4K
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

21.2K

Related Concept Videos

Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.3K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.2K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.2K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
4.4K
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
1.3K
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
57