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Bone morphological analyses in Spontaneously Diabetic Torii (SDT) fatty rats
Takeshi Ohta1, Shuichi Kimura, Masaya Hirata
1Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
The Journal of Veterinary Medical Science
|May 26, 2015
Summary
The Spontaneously Diabetic Torii (SDT) fatty rat, a model for type 2 diabetes, exhibits bone abnormalities. This study found reduced bone thickness and increased bone area in the tibia, suggesting it is a valuable model for diabetic osteoporosis research.
Area of Science:
- Endocrinology
- Bone Biology
- Diabetology
Background:
- Spontaneously Diabetic Torii (SDT) fatty rats are a model for obese type 2 diabetes.
- Previous studies noted quantitative bone abnormalities, specifically low bone mineral density (BMD).
Purpose of the Study:
- To investigate bone morphological and qualitative abnormalities in SDT fatty rats.
- To assess the utility of SDT fatty rats in studying diabetic osteoporosis.
Main Methods:
- Analysis of bone morphology in the proximal tibia of male SDT fatty rats.
- Quantitative assessment of trabecular bone parameters.
Main Results:
- SDT fatty rats displayed increased total trabecular area and trabecular number.
- A decrease in trabecular thickness was observed, indicating trabecular miniaturization.
- These changes suggest qualitative bone abnormalities.
Conclusions:
- SDT fatty rats exhibit specific bone morphological changes, including trabecular miniaturization.
- The SDT fatty rat is a suitable model for investigating the bone quality changes associated with diabetic osteoporosis.
