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Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

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Related Experiment Video

Updated: Apr 12, 2026

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

Primed and ready: understanding lineage commitment through single cell analysis.

Rachael A Nimmo¹, Gillian E May¹, Tariq Enver¹

¹University College London (UCL) Cancer Institute, Huntley Street, London WC1E 6BT, UK.

Trends in Cell Biology

|May 26, 2015

Summary

This summary is machine-generated.

Single-cell analysis reveals how multipotential cells make lineage commitment decisions. Understanding this process is crucial for hematopoietic stem cell research and immune responses.

Keywords:

commitment hematopoiesis hematopoietic stem cell multilineage priming single cell

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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Last Updated: Apr 12, 2026

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

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Published on: December 18, 2015

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Area of Science:

Hematopoiesis
Stem cell biology
Cellular differentiation

Background:

Multipotential hematopoietic stem cells (HSCs) maintain blood production throughout life.
Lineage commitment is essential for balanced blood output and immune response.
Population-level studies mask crucial cellular heterogeneity in HSCs.

Purpose of the Study:

To review single-cell studies on hematopoietic lineage commitment.
To highlight the importance of single-cell analysis in understanding cell fate decisions.
To discuss future technologies for studying lineage commitment.

Main Methods:

Review of single-cell expression profiling studies.
Analysis of single-cell imaging data.
Examination of clonal tracking studies in hematopoiesis.

Main Results:

Single-cell approaches reveal heterogeneity in stem cell populations.
These methods provide insights into the mechanics of lineage commitment.
Recent studies have advanced understanding of hematopoietic cell fate choices.

Conclusions:

Single-cell analysis is critical for dissecting lineage commitment.
New technologies will further elucidate stem cell differentiation.
Understanding commitment is key for regenerative medicine and disease treatment.