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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Sedative premedication before surgery--A multicentre randomized study versus placebo.

Laurent Beydon1, Adrien Rouxel1, Nicolas Camut1

  • 1Pôle d'anesthésie réanimation, LUNAM université, CHU d'Angers, 49000 Angers, France.

Anaesthesia, Critical Care & Pain Medicine
|May 26, 2015
PubMed
Summary

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This summary is machine-generated.

Preoperative anxiety medication before surgery is no more effective than a placebo. Both anxiolytics and hypnotics showed no significant benefit over placebo in reducing patient anxiety during surgery.

Area of Science:

  • Anesthesiology
  • Perioperative Medicine
  • Psychopharmacology

Background:

  • Anxiolytic premedication's role in non-ambulatory surgery is questioned due to improved preoperative information.
  • Oral hypnotics may offer comparable anxiety relief to anxiolytics before surgery.

Purpose of the Study:

  • To compare the efficacy of zopiclone (hypnotic) and alprazolam (anxiolytic) against a placebo for preoperative anxiety in non-ambulatory surgery.
  • To assess the non-inferiority of these strategies to each other and superiority to placebo.

Main Methods:

  • A double-blind, randomized, multicentre study involving non-ambulatory surgical patients.
  • Patients received zopiclone, alprazolam, or placebo.
  • Anxiety, fear, and mood were assessed preoperatively and in the operating room.
Keywords:
AnxietyBenzodiazepinesPremedicationRandomized controlled trialSurgery

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Main Results:

  • No significant difference in anxiety or comfort levels was observed between zopiclone, alprazolam, and placebo groups in the operating room.
  • Preoperative anxiety levels correlated with anxiety in the operating room, regardless of treatment.
  • Zopiclone significantly improved sleep quality the night before surgery compared to other groups.

Conclusions:

  • Premedication with anxiolytics or hypnotics offers no significant advantage over placebo for non-ambulatory surgery.
  • The moderate level of patient anxiety may contribute to the observed lack of efficacy for premedication strategies.