Related Experiment Video
Updated: Apr 12, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Endometriosis in adolescents.
Erica C Dun1, Kimberly A Kho2, Vadim V Morozov3
1Department of Obstetrics, Gynecology, and Reproductive Science, Yale School of Medicine, New Haven, Connecticut, USA.
Adolescent endometriosis diagnosis is often delayed, impacting treatment. Laparoscopic diagnosis and treatment in adolescents with pelvic pain lead to favorable outcomes, with most experiencing pain resolution post-surgery.
Area of Science:
- Reproductive Medicine
- Adolescent Gynecology
- Surgical Diagnosis
Background:
- Endometriosis symptoms frequently begin in adolescence but diagnosis is often delayed.
- Adolescents with pelvic pain undergo laparoscopy for diagnosis and treatment of endometriosis.
- Delayed diagnosis impacts the patient's journey and treatment effectiveness.
Purpose of the Study:
- To describe the experiences of adolescents diagnosed with endometriosis via laparoscopy for pelvic pain.
- To analyze symptoms, diagnostic timelines, healthcare encounters, and treatment outcomes.
- To identify factors influencing diagnosis and postoperative results in young patients.
Main Methods:
- Retrospective review of 25 female patients aged ≤21 years diagnosed with endometriosis during laparoscopy.
- Data collected over an 8-year period, with 1-year postoperative follow-up.
- Analysis of symptoms, time to diagnosis, number/type of physicians consulted, disease stage, and treatment outcomes.
Main Results:
- Mean age at surgery was 17.2 years; common symptoms included dysmenorrhea, abnormal uterine bleeding, and gastrointestinal/genitourinary issues.
- Average time from symptom onset to diagnosis was 22.8 months, with a median of 3 physicians consulted.
- Most patients had Stage I disease, and 80% reported resolved or improved pain at 1 year post-surgery.
Conclusions:
- Expedited care through timely referral to experienced gynecologists is crucial for adolescents with endometriosis.
- Laparoscopic diagnosis and treatment of endometriosis in adolescents yield favorable outcomes.
- Adolescents with endometriosis benefit from appropriate hormonal and nonhormonal therapies post-diagnosis.
More Related Videos
07:12A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
07:20Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
Published on: December 21, 2012
Related Concept Videos
Oogenesis
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Ovarian Cycle
Disorders of the Female Reproductive System
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of...