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Homocystein as a risk factor for developing complications in chronic renal failure
Biljana Jakovljevic1, Branislav Gasic2, Pedja Kovacevic3
1International Dialysis Center Banjaluka, DC Laktasi, Bosnia and Herzegovina.
Materia Socio-Medica
|May 26, 2015
Summary
Homocysteine is elevated in chronic renal failure patients. In hemodialysis patients, higher homocysteine correlates with longer dialysis, anemia, and lower LDL cholesterol, but not age.
Area of Science:
- Nephrology
- Cardiology
- Clinical Chemistry
Background:
- Cardiovascular diseases (CVD) are a primary cause of mortality in individuals with chronic renal failure (CRF).
- Homocysteine is recognized as a nontraditional risk factor for CVD.
- Understanding risk factors in CRF patients is crucial for improving outcomes.
Purpose of the Study:
- To investigate the association between homocysteine levels and traditional and nontraditional CVD risk factors.
- To compare these associations in pre-dialysis and hemodialysis patient cohorts.
Main Methods:
- Study included 33 pre-dialysis (CKD stages 3-4) and 43 hemodialysis patients.
- Measured homocysteine, blood pressure, standard lab parameters, glomerular filtration rate (pre-dialysis), and dialysis quality (hemodialysis).
Main Results:
- Elevated homocysteine levels (19±5.42mmol/l) were observed in all CRF patients.
- No significant correlation between homocysteine and CVD risk factors was found in pre-dialysis patients.
- In hemodialysis patients, homocysteine showed negative correlation with age (p<0.05) and positive correlation with dialysis duration (p<0.01) and anemia parameters (p<0.01).
- Homocysteine also demonstrated a negative correlation with LDL cholesterol and total cholesterol (p<0.01).
Conclusions:
- Homocysteine is elevated in all chronic renal failure patients.
- Positive correlations between homocysteine and other CVD risk factors were identified in hemodialysis patients, including dialysis duration and anemia.
- These findings highlight the complex interplay of risk factors in CRF patients undergoing dialysis.
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