Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

950
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
950
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

691
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
691
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

350
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
350
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

559
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
559
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

753
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
753
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

117
The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
117

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The landscape of serum autoantibodies in lupus nephritis.

Autoimmunity reviews·2026
Same author

SGLT2i, anti-endothelin A and double endothelin and angiotensin inhibitors: a new future for chronic kidney disease in children.

Pediatric nephrology (Berlin, Germany)·2026
Same author

[Application of a Sequential Blood Purification Approach in a Complex Critically Ill Patient].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2026
Same author

Evolving kidney disease phenotypes in type 2 diabetes: declining albuminuria and increasing isolated low eGFR.

Clinical kidney journal·2026
Same author

Triglyceride-glucose index and its derived anthropometric indices: a comparative analysis for mortality prediction in the population cohort of the URRAH study.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2026
Same author

New Anticomplement Drugs in Nephrology: Mechanism and Indication.

Kidney & blood pressure research·2026

Related Experiment Video

Updated: Apr 12, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

4.6K

[Hyperuricemia and renal risk].

Francesca Viazzi, Barbara Bonino, Elena Ratto

    Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
    |May 26, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Elevated uric acid is linked to chronic kidney disease complications like hypertension. Urate-lowering therapy may help prevent or manage kidney disease progression.

    More Related Videos

    Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
    03:19

    Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

    Published on: June 21, 2024

    2.9K
    Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
    07:45

    Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

    Published on: February 9, 2021

    4.1K

    Related Experiment Videos

    Last Updated: Apr 12, 2026

    Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
    10:02

    Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

    Published on: October 3, 2020

    4.6K
    Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
    03:19

    Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

    Published on: June 21, 2024

    2.9K
    Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
    07:45

    Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

    Published on: February 9, 2021

    4.1K

    Area of Science:

    • Nephrology
    • Metabolic Diseases
    • Cardiovascular Health

    Background:

    • Recent research highlights a connection between high uric acid levels and chronic kidney disease (CKD) comorbidities.
    • Conditions such as hypertension, cardiovascular disease, cerebral disease, and insulin resistance are frequently associated with elevated serum uric acid.

    Purpose of the Study:

    • To explore the potential pathogenetic mechanisms linking serum uric acid levels to renal damage.
    • To evaluate the role of urate-lowering therapy in the primary or secondary prevention of chronic kidney disease.

    Main Methods:

    • Review of existing literature on uric acid, chronic kidney disease, and related comorbidities.
    • Analysis of cellular and tissue-level pathogenetic mechanisms.
    • Examination of evidence supporting urate-lowering therapy's impact on renal morbidity.

    Main Results:

    • Established association between elevated uric acid and CKD-related conditions.
    • Identified potential cellular and tissue mechanisms contributing to renal damage from high uric acid.
    • Growing evidence suggests urate-lowering therapy correlates with reduced renal morbidity.

    Conclusions:

    • Serum uric acid levels are significantly associated with chronic kidney disease and its complications.
    • Therapeutic interventions targeting uric acid reduction show promise for CKD prevention and management.
    • Urate-lowering therapy could be a valuable strategy in managing patients with or at risk for chronic kidney disease.