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Updated: Apr 12, 2026
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Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
Published on: April 13, 2022
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A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids
Daniel J Foley1, Richard G Doveston, Ian Churcher
1School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK. s.p.marsden@leeds.ac.uk a.s.nelson@leeds.ac.uk.
Chemical Communications (Cambridge, England)
|May 27, 2015
Abstract:
A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.
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