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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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Manadodioxans A-E: polyketide endoperoxides from the marine sponge Plakortis bergquistae

Masaki Gushiken1, Ippei Kagiyama, Hikaru Kato

  • 1Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.

Journal of Natural Medicines
|May 27, 2015
PubMed
Summary

Five new compounds called manadodioxans were discovered in a marine sponge. Manadodioxan E demonstrated antimicrobial properties against Escherichia coli, while manadodioxan D did not.

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