Related Experiment Video
Updated: Apr 12, 2026
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
IgSimulator: a versatile immunosequencing simulator
Yana Safonova1, Alla Lapidus1, Jennie Lill2
1Center of Algorithmic biotechnology, Institute of Translational Biomedicine, St. Petersburg State University, Russia, Algorithmic Biology Laboratory, St. Petersburg Academic University, St. Petersburg, Russia and.
Motivation:
The recent introduction of next-generation sequencing technologies to antibody studies have resulted in a growing number of immunoinformatics tools for antibody repertoire analysis. However, benchmarking these newly emerging tools remains problematic since the gold standard datasets that are needed to validate these tools are typically not available.
Results:
Since simulating antibody repertoires is often the only feasible way to benchmark new immunoinformatics tools, we developed the IgSimulator tool that addresses various complications in generating realistic antibody repertoires. IgSimulator's code has modular structure and can be easily adapted to new requirements to simulation.
Availability And Implementation:
IgSimulator is open source and freely available as a C++ and Python program running on all Unix-compatible platforms. The source code is available from yana-safonova.github.io/ig_simulator.
Contact:
safonova.yana@gmail.com
Supplementary Information:
Supplementary data are available at Bioinformatics online.
More Related Videos
08:26Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
13:13Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques
Published on: September 25, 2018
