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Metal nanoparticles: a theranostic nanotool against cancer
Harshita Sharma1, Pawan K Mishra2, Sushama Talegaonkar3
1Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India; Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.
Abstract:
Cancer remains one of the most deadly diseases worldwide, but conventional anticancer therapies come with several drawbacks. Therefore, there is a need to develop new anticancer strategies. Theranostics is a strategy that combines treatment with diagnosis and monitoring. Metal nanoparticles are proposed as one of the most promising theranostic agents for the treatment of cancer. Thus, metals including iron, gold (Au), silver (Ag), zinc (Zn), and titanium, have potential as anticancer agents, either inherently or as a result of surface modifications. As a functional component of theranostic tools, metal nanoparticles have crucial dual roles as a diagnostic and active therapeutic agent for the treatment of cancer.
Insights
Metal nanoparticles offer a promising new approach to cancer treatment by combining diagnosis and therapy. These agents, including iron, gold, and silver nanoparticles, show potential for enhanced anticancer strategies.
Area of Science:
- Oncology
- Nanotechnology
- Materials Science
Background:
- Conventional cancer therapies present significant limitations and side effects.
- There is a critical need for innovative and more effective anticancer strategies.
- Theranostics, integrating diagnosis with targeted therapy, is an emerging field.
Purpose of the Study:
- To explore the potential of metal nanoparticles as theranostic agents for cancer treatment.
- To highlight the dual role of metal nanoparticles in cancer diagnosis and therapy.
- To review various metals with anticancer potential in nanoparticle form.
Main Methods:
- Review of existing literature on metal nanoparticles in cancer theranostics.
- Analysis of the inherent and surface-modified properties of metal nanoparticles for anticancer activity.
- Examination of the diagnostic and therapeutic applications of functionalized metal nanoparticles.
Main Results:
- Metal nanoparticles, including iron, gold (Au), silver (Ag), zinc (Zn), and titanium, demonstrate significant potential as anticancer agents.
- Surface modifications can enhance the inherent anticancer efficacy of these nanoparticles.
- Metal nanoparticles effectively function as dual-action agents for both cancer diagnosis and therapy.
Conclusions:
- Metal nanoparticles represent a highly promising platform for advancing cancer theranostics.
- Their ability to combine diagnostic and therapeutic functions offers a significant advantage over conventional treatments.
- Further research into metal nanoparticle-based theranostics could lead to improved cancer patient outcomes.
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