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Updated: Apr 11, 2026

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

Closed-Loop Optogenetic Brain Interface.

Ramin Pashaie, Ryan Baumgartner, Thomas J Richner

IEEE Transactions on Bio-Medical Engineering

|May 27, 2015

Summary

This summary is machine-generated.

This study introduces a novel closed-loop brain-machine interface using optogenetics and micro-ECoG. The system enables real-time neural activity modulation for advanced brain-computer applications.

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Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

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Related Experiment Videos

Last Updated: Apr 11, 2026

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

Published on: September 2, 2013

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

Area of Science:

Neuroscience
Biomedical Engineering
Optogenetics

Background:

Developing effective closed-loop brain-machine interfaces (BMIs) is crucial for understanding neural circuits and creating advanced prosthetics.
Existing methods often lack the precision and real-time feedback necessary for complex neural modulation.

Purpose of the Study:

To present a novel platform integrating optogenetic stimulation with micro-electrocorticography (micro-ECoG) for closed-loop BMI implementation.
To demonstrate the system's capability for real-time neural activity monitoring and targeted modulation.

Main Methods:

Utilized micro-fabricated, optically transparent micro-ECoG devices for simultaneous electrophysiology and optical access.
Developed an integrated optical setup for patterned optogenetic stimulation and fluorescence microscopy.
Implemented closed-loop algorithms using micro-ECoG feedback to adjust stimulation parameters.

Main Results:

Successfully demonstrated a closed-loop system where neural activity recorded by micro-ECoG guided optogenetic stimulation.
Achieved real-time modulation of neural activity to follow predefined spatial-temporal patterns.
Validated the platform's efficacy in closed-loop paradigms.

Conclusions:

The developed platform offers a powerful tool for precise, real-time control of neural circuits.
This approach advances the development of sophisticated brain-machine interfaces for research and therapeutic applications.