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Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway

M Baroni1, G Pavani2, M Pinotti1

  • 1Department of Life Sciences and Biotechnology, University of Ferrara, Italy.

Biochimica Et Biophysica Acta
|May 28, 2015
PubMed
Summary

Arginine 386 in coagulation factor X (FX) is crucial for activation by the intrinsic pathway. Mutations here reduce thrombin generation, impacting coagulation and potentially explaining bleeding tendencies.

Keywords:
Activation determinantAmino acid substitutionCoagulation serine proteasesFactor XFactor X deficiencyRecombinant expression

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