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Updated: Apr 11, 2026

Modeling and Imaging 3-Dimensional Collective Cell Invasion

Modeling and Imaging 3-Dimensional Collective Cell Invasion

Published on: December 7, 2011

Three-dimensional cage-like microscaffolds for cell invasion studies.

Barbara Spagnolo¹, Virgilio Brunetti², Godefroy Leménager²

¹1] Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Via Barsanti, 73010 Arnesano (Lecce), Italy [2] Dipartimento di Ingegneria dell'Innovazione, Università del Salento, via per Monteroni, 73100 Lecce, Italy.

Scientific Reports

|May 28, 2015

Summary

This study introduces 3D microstructures to analyze cancer cell migration through small pores. The findings reveal that pore size discrimination correlates with metastatic potential, aiding in distinguishing between cancerous and non-cancerous breast cells.

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Published on: October 25, 2018

Related Experiment Videos

Last Updated: Apr 11, 2026

Modeling and Imaging 3-Dimensional Collective Cell Invasion

Modeling and Imaging 3-Dimensional Collective Cell Invasion

Published on: December 7, 2011

A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting

A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting

Published on: November 20, 2015

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Published on: October 25, 2018

Area of Science:

Biomedical Engineering
Cancer Biology
Cellular Mechanics

Background:

Cancer cell motility is crucial for metastasis, involving migration through the extracellular matrix.
The extracellular matrix's properties influence tumor cell invasion and migration parameters.

Purpose of the Study:

To develop and utilize 3D complex cage-like microstructures for analyzing cancer cell migration.
To investigate cell migration through pores significantly smaller than the cell nucleus.
To establish a method for discriminating between tumorigenic and non-tumorigenic cells based on migration behavior.

Main Methods:

Fabrication of 3D complex cage-like microstructures using two-photon (TP) direct laser writing (DLW).
Analysis of cancer cell migration through microstructures with varying pore sizes.
Correlation of cell traversal ability with metastatic potential and invasiveness of different cell lines.

Main Results:

Cancer cell migration through pores is dependent on metastatic potential and invasiveness.
A specific pore-area threshold was identified that effectively discriminates between non-tumorigenic and tumorigenic human breast cells.
The study demonstrates the utility of TP-DLW fabricated microstructures for probing cell invasion.

Conclusions:

3D microstructures fabricated by TP-DLW offer a novel platform for studying cell migration dynamics.
Migration through restrictive pores serves as a reliable indicator of a cell line's metastatic capability.
This approach provides a quantitative method for assessing tumorigenicity and invasiveness in breast cancer research.