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Updated: Apr 11, 2026
09:04
Isolation and Culture of Embryonic Mouse Neural Stem Cells
Published on: November 11, 2018
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Is mouse embryonic stem cell technology obsolete?
1Stem Cell Engineering, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. skarnes@sanger.ac.uk.
Genome Biology
|May 28, 2015
Abstract:
Injection of recombinant Cas9 protein and synthetic guide RNAs into mouse zygotes has been shown to facilitate gene disruption and knock-ins using the CRISPR system. These technologies may soon displace genetic modification using embryonic stem cells.
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