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Updated: Apr 11, 2026

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

Published on: October 21, 2014

Ghost cell lesions.

E Rajesh¹, Sudha Jimson¹, K M K Masthan¹

¹Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath University, Chennai, Tamil Nadu, India.

Journal of Pharmacy & Bioallied Sciences

|May 28, 2015

Summary

This summary is machine-generated.

Ghost cells, also known as shadow cells, are enlarged, anucleated epithelial cells appearing in various lesions. This review explores their origin, nature, and significance in neoplasms.

Keywords:

Ameloblastic fibroma ghost cell odontogenic pilomatricoma

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Area of Science:

Oral pathology
Histopathology
Neoplasm biology

Background:

Ghost cells are enlarged epithelial cells lacking nuclei, presenting a characteristic 'shadowy' appearance in H&E staining.
Also referred to as shadow cells or translucent cells, their presence is noted in both odontogenic and non-odontogenic lesions.
The exact origin and biological significance of ghost cells have been a long-standing topic of debate in pathology.

Purpose of the Study:

To review the current understanding of ghost cell formation.
To elucidate the diverse nature and characteristics of ghost cells across different pathological entities.
To discuss the diagnostic and prognostic significance of ghost cells in various neoplasms.

Main Methods:

Literature review of existing studies on ghost cells.
Analysis of histopathological features associated with ghost cells.
Synthesis of information regarding the origin and implications of ghost cells in neoplasms.

Main Results:

Ghost cells exhibit variable morphology depending on the specific lesion.
Their presence is associated with a range of odontogenic and non-odontogenic neoplasms.
Understanding their nature is crucial for accurate diagnosis and management.

Conclusions:

Ghost cells represent a specific cellular change with implications in neoplastic processes.
Further research is needed to fully comprehend their role in tumorigenesis.
Recognizing ghost cells aids in the differential diagnosis of various oral lesions.