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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
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Structural Joints: Fibrous Joints01:03

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Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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Fractures: Bone Repair01:27

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
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Fibrous dysplasia-recent concepts.

N Anitha1, S Leena Sankari1, L Malathi1

  • 1Department of Oral Pathology, Sree Balaji Dental College and Hospital, Bharath University, Chennai, Tamil Nadu, India.

Journal of Pharmacy & Bioallied Sciences
|May 28, 2015
PubMed
Summary

Fibrous dysplasia (FD) is a benign bone disorder where fibrous tissue replaces normal bone. While often asymptomatic and incidentally found, managing FD remains a clinical challenge.

Keywords:
Bonefibro-osseous lesionsfibrous dysplasia

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Area of Science:

  • Orthopedics
  • Pathology
  • Genetics

Background:

  • Fibrous dysplasia (FD) is a benign intramedullary fibro-osseous lesion.
  • It represents a bone developmental anomaly where normal bone and marrow are replaced by fibrous tissue.
  • FD can manifest as monostotic, polyostotic, or panostotic forms, frequently affecting long bones.

Purpose of the Study:

  • To provide a comprehensive overview of fibrous dysplasia.
  • To highlight the diagnostic criteria and challenges in managing this condition.
  • To discuss the current understanding of FD's etiology and presentation.

Main Methods:

  • Review of clinical, radiological, and histopathological findings.
  • Analysis of disease presentation and common affected sites.
  • Discussion of available treatment options and management strategies.

Main Results:

  • Fibrous dysplasia is characterized by the replacement of bone and marrow with fibrous tissue.
  • Long bones are the most commonly affected sites, often discovered incidentally.
  • Diagnosis relies on a combination of clinical, radiographic, and histopathological evidence.

Conclusions:

  • Fibrous dysplasia is a complex developmental bone anomaly.
  • Accurate diagnosis requires integrated findings from multiple modalities.
  • Effective management of fibrous dysplasia continues to be a significant clinical challenge.