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08:56
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Fulminant hyperkalaemia and multiple complications following ibuprofen overdose
D G Menzies1, A G Conn, I J Williamson
1Regional Poisoning Treatment Centre, Edinburgh, Scotland.
Medical Toxicology and Adverse Drug Experience
|November 1, 1989
Summary
A severe ibuprofen overdose in a teenager caused a hypermetabolic state, respiratory failure, and dangerous hyperkalemia. Prompt treatment of potassium levels resolved the cardiac arrhythmia, but lung abnormalities persisted.
Area of Science:
- Toxicology
- Cardiology
- Pulmonology
Background:
- This case report details a severe ibuprofen and doxepin overdose in a previously healthy 17-year-old male.
- The patient presented with coma and was initially treated for mild hypokalemia.
Observation:
- The patient developed a hypermetabolic state with fever, metabolic acidosis, and respiratory failure 14 hours post-admission.
- A malignant broad complex tachycardia associated with acute hyperkalemia (8.3 mmol/L) was observed.
Findings:
- The cardiac arrhythmia resolved upon correction of hyperkalemia.
- Diffuse lung opacification, transient renal dysfunction, and mild rhabdomyolysis were noted.
- Persistent bilateral nodular shadowing on chest x-ray was observed at 4-week follow-up.
Implications:
- Severe ibuprofen overdose can precipitate life-threatening metabolic and cardiac complications.
- Management requires close monitoring of electrolytes, acid-base balance, and respiratory function.
- Long-term pulmonary sequelae may occur following severe overdose.
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