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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

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AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

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Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
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Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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Rhupus; unusual presentations.

Ora Shovman1, Pnina Langevitz1,2, Yehuda Shoenfeld3,4,5

  • 1Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel.

Clinical Rheumatology
|May 29, 2015
PubMed
Summary
This summary is machine-generated.

Rhupus, a rare condition combining systemic lupus erythematosus and rheumatoid arthritis, can present with severe, life-threatening complications. Rheumatologists must recognize these potential risks, including antiphospholipid syndrome and malignancies.

Keywords:
AutoantibodiesLupusRheumatoid arthritisRhupus

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Area of Science:

  • Rheumatology
  • Autoimmune Diseases
  • Clinical Case Studies

Background:

  • Rhupus, the co-occurrence of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), is uncommon.
  • Typically, Rhupus patients exhibit more RA features with minimal SLE-related organ damage.
  • Progressive or life-threatening manifestations are infrequently reported in Rhupus.

Observation:

  • This report details three Rhupus cases, two with coexisting antiphospholipid syndrome (APS).
  • One patient presented with severe Raynaud's syndrome, digital ulcers, APS, pulmonary hypertension, and two malignancies.
  • Literature review revealed limited cases of Rhupus with secondary APS and severe Raynaud's syndrome.

Findings:

  • Rhupus patients show a high prevalence of antiphospholipid antibodies, similar to SLE, but not always linked to APS.
  • Pulmonary hypertension and malignancies are novel, previously unreported complications in Rhupus syndrome.
  • Severe Raynaud's syndrome with digital ulcers and secondary APS are rare but documented associations.

Implications:

  • Clinicians should consider the potential for severe, progressive conditions in Rhupus patients.
  • Awareness of associations with APS, severe Raynaud's, pulmonary hypertension, and malignancies is crucial for timely diagnosis and management.
  • This highlights the need for vigilant monitoring in Rhupus cases for rare but serious comorbidities.