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Peripheral interleukin-6 promotes resilience versus susceptibility to inescapable electric stress
Chun Yang1, Yukihiko Shirayama1, Ji-Chun Zhang1
11Division of Clinical Neuroscience,Chiba University Center for Forensic Mental Health,Chiba,Japan.
Objective:
Accumulating evidences suggest that pro-inflammatory cytokines such as interleukin-6 (IL-6) play a role in the pathophysiology of depression. In the learned helplessness (LH) paradigm, ~35% rats are resilient to inescapable stress.
Methods:
Levels of IL-6 in the serum and medial prefrontal cortex (mPFC) of LH rats (susceptible) and non-LH rats (resilience) were measured using enzyme-linked immunosorbent assay and western blot analysis, respectively.
Results:
Serum levels of IL-6 in the LH rats were significantly higher than those of control and non-LH rats. In contrast, tissue levels of IL-6 in the mPFC were not different among three groups.
Conclusion:
The results suggest that peripheral IL-6 may contribute to resilience versus susceptibility to inescapable stress.
