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Epiglottic Squamous Cell Carcinoma Showing Unexpected 18F-FDOPA Uptake on PET/CT Investigation
Sebastien Dietemann1, Christian Debry, Aline Onea
1From the Departments of *Biophysics and Nuclear Medicine, †Otolaryngology and Maxillofacial Surgery, and ‡Pathology, University Hospitals of Strasbourg; and §ICube, University of Strasbourg/CNRS (UMR 7357) and FMTS, Faculty of Medicine, Strasbourg, France.
Abstract:
We report the unexpected findings of ¹⁸F-fluorodihydroxyphenylalanine (¹⁸F-FDOPA) PET/CT performed in a patient with a history of ileal carcinoid. A focally increased ¹⁸F-FDOPA uptake was detected in the left side of the epiglottis corresponding to a laryngeal squamous cell carcinoma. Interestingly, uptake of 3-O-methyl-6-¹⁸F-fluoro-L-dihydroxyphenylalanine, a metabolite of ¹⁸F-FDOPA, has been previously reported in both squamous cell carcinoma cell lines and the corresponding mouse tumor xenograft models. Although ¹⁸F-FDOPA is mainly used in patients with neuroendocrine tumors, ¹⁸F-FDOPA is not a neuroendocrine tumor-specific radiotracer.
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