Related Experiment Video
Updated: Apr 11, 2026

Minimally Invasive Muscle Embedding MIME - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis
Published on: August 24, 2017
Galen's (130-201 AD) Conceptions of the Heart
Marianna Karamanou1, Christodoulos Stefanadis, Gregory Tsoucalas
1History of Medicine Department, University of Athens, Medical School, Athens, Greece.
Insights
Galen
Area of Science:
- Cardiovascular Physiology
- History of Medicine
Background:
- Galen's significant contributions to cardiovascular knowledge in the 2nd century AD.
- His anatomical and physiological understanding laid groundwork for future research.
Discussion:
- Galen's theory of blood circulation was fundamentally flawed.
- He inaccurately proposed venous blood moved through the heart's septum.
Key Insights:
- The erroneous septum pore theory impeded cardiovascular science for over 1500 years.
- Galen's incorrect model hindered progress in understanding blood flow.
Outlook:
- Revisiting historical medical theories highlights the evolution of scientific understanding.
- Understanding past misconceptions is crucial for appreciating current cardiovascular physiology.
Abstract:
In the 2nd century AD, the prolific Greek physician Galen contributed significantly to the anatomical and physiological knowledge of the cardiovascular system. However his erroneous theory of blood circulation, based on the inaccurate notion that venous blood passes through tiny pores in the heart's septum, moves from the right ventricle to the left, and is mixed with inhaled air from the lungs, was to block any new ideas in this field for more than 1500 years.

