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Related Experiment Video

Updated: Apr 11, 2026

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response

Published on: August 10, 2017

Seasonal effects on gene expression.

Anita Goldinger¹, Konstantin Shakhbazov², Anjali K Henders³

¹University of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland 4102, Australia; The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia.

|May 30, 2015

Summary

Seasonal changes impact gene expression and blood cell counts in healthy individuals. Key findings reveal variations in DNA repair and immune function genes throughout the year.

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Last Updated: Apr 11, 2026

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response

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Published on: August 10, 2017

Author Spotlight: Enhancements in Gene Expression Regulation Research

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The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

Area of Science:

Genomics
Immunology
Chronobiology

Background:

Many health conditions exhibit seasonal variations in onset and severity.
Understanding the molecular basis of these seasonal health patterns is crucial.

Purpose of the Study:

To investigate seasonal variations in the human transcriptome.
To identify molecular processes and blood cell compositions influenced by seasonal cycles.

Main Methods:

Analysis of transcriptome data from 606 healthy individuals.
Correlation of gene expression patterns with a 12-month seasonal cycle.
Assessment of blood cell counts and their association with seasonal variability.

Main Results:

Identified 74 transcripts linked to a 12-month seasonal cycle, enriched in DNA repair and binding processes.
Found 94 transcripts with seasonal variability influenced by blood cell counts, enriched in immune function.
Observed significant seasonal associations with erythrocyte, platelet, neutrophil, monocyte, and CD19 cell counts.

Conclusions:

Seasonal variation is a significant environmental regulator of gene expression and blood cell composition.
Immune cell physiology, including leukocyte counts and immune-related gene expression, varies seasonally in healthy individuals.