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Diffusion-weighted MRI in the follow-up of chronic periaortitis

L Kamper1, P Haage1, A S Brandt2

  • 11 Department of Diagnostic and Interventional Radiology, HELIOS Klinikum Wuppertal, University Hospital Witten/Herdecke, Wuppertal, Germany.

The British Journal of Radiology
|May 30, 2015
PubMed
Abstract

Insights

Diffusion-weighted MRI (DWI) effectively monitors treatment response in chronic periaortitis (CP) patients. This non-contrast imaging technique shows significant changes in CP tissue, aiding disease activity assessment and guiding therapy.

Area of Science:

  • Radiology
  • Medical Imaging
  • Oncology

Background:

  • Chronic periaortitis (CP) is a challenging condition requiring effective monitoring.
  • Assessing treatment response in CP often relies on invasive or contrast-enhanced methods.

Purpose of the Study:

  • To evaluate the utility of diffusion-weighted MRI (DWI) for intraindividual follow-up of patients with chronic periaortitis (CP) undergoing medical therapy.
  • To determine if DWI can assess treatment response without the need for contrast agents.

Main Methods:

  • Retrospective analysis of MRI data from 21 newly diagnosed CP patients before and after a median of 16 weeks of medical treatment.
  • Analysis of DWI parameters (b800 signal, apparent diffusion coefficient [ADC] values) in CP and psoas muscle, alongside disease extent and contrast enhancement.
  • Correlation of MRI findings with laboratory inflammation markers.

Main Results:

  • Significant decrease in b800 signal intensity and increase in ADC values in periaortic tissue post-treatment (p ≤ 0.0001).
  • Statistically significant reduction in CP extent and contrast enhancement (p ≤ 0.0001).
  • No significant changes observed in psoas muscle parameters.

Conclusions:

  • Diffusion-weighted MRI (DWI) is a valuable tool for assessing treatment response in chronic periaortitis (CP) without contrast agents.
  • DWI can detect significant intraindividual changes in CP, potentially guiding therapeutic strategies and disease management.

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