Related Experiment Videos
Increased risk of intracerebral hemorrhage among patients with chronic osteomyelitis
Chun-Hung Tseng1,2, Wei-Shih Huang1,2, Chih-Hsin Muo3
1Department of Neurology and.
Insights
Chronic osteomyelitis (COM) is linked to a higher risk of intracerebral hemorrhage (ICH), particularly in younger individuals. This inflammatory condition may increase ICH incidence, underscoring the need for further investigation.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- Inflammation can lead to cerebral arteriolar ectasia, microaneurysm formation, and intracerebral hemorrhage (ICH).
- Chronic osteomyelitis (COM) is an inflammatory disorder with a potential, yet unstudied, role in ICH risk.
Purpose of the Study:
- To investigate the association between chronic osteomyelitis (COM) and the risk of intracerebral hemorrhage (ICH).
Main Methods:
- A cohort study utilized Taiwan's national insurance inpatient claims data.
- 22,052 patients diagnosed with COM were compared to 88,207 matched controls without COM.
- Risks of ICH were analyzed considering comorbidities like hypertension and diabetes.
Main Results:
- Patients with COM had a 1.68 times higher incidence of ICH compared to controls (adjusted HR 1.50).
- The risk of ICH associated with COM was significantly higher in younger age groups (adjusted HR 3.28 for <40 years).
- ICH risk increased with COM severity, with severe cases showing an adjusted HR of 4.42.
Conclusions:
- Chronic osteomyelitis (COM) is identified as an inflammatory factor associated with an increased risk of intracerebral hemorrhage (ICH).
- The association between COM and ICH risk is particularly pronounced in younger patient populations.
Object:
Inflammation may provoke cerebral arteriolar ectasia, inducing microaneurysm formation and further promoting intracerebral hemorrhage (ICH). Chronic osteomyelitis (COM) is an inflammatory disorder for which study of its role in ICH is lacking. This study explored whether COM increases the risk of ICH.
Methods:
From Taiwan national insurance inpatient claims, 22,052 patients who were newly diagnosed with COM between 1997 and 2010 were identified; 88, 207 age and sex frequency-matched subjects without COM were selected at random for comparison. Risks of ICH associated with COM and comorbidities, including hypertension, diabetes, hyperlipidemia, chronic kidney disease, and drug abuse, were assessed by the end of 2010.
Results:
The incidence of ICH was 1.68 times higher in the COM cohort than in the comparison cohort, with an adjusted hazard ratio (HR) of 1.50 (95% CI 1.29-1.74) estimated in the multivariable Cox model. Age-specific analysis showed that the HR of ICH for COM patients decreased with age, with an adjusted HR of 3.28 (95% CI 1.88-5.75) in the < 40-year age group, which declined to 1.11 (95% CI 0.88-1.40) in the elderly. The incidence of ICH increased with the severity of COM; for those with severe COM the adjusted HR was 4.42 (95% CI 3.31-5.89). For subjects without comorbidities, the incidence of ICH was 1.20-fold (95% CI 1.00-1.45) higher in the COM cohort than in the comparison cohort.
Conclusions:
This study suggests for the first time that COM is an inflammatory factor associated with increased risk of ICH, especially in younger patients.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...