Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dietary Connections01:23

Dietary Connections

66.3K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
66.3K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

922
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
922
Regulation of Food Intake01:30

Regulation of Food Intake

3.2K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.2K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

512
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
512
Lipid Digestion01:06

Lipid Digestion

107.8K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
107.8K
Peroxisomes01:24

Peroxisomes

22.2K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
22.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Lactarius deliciosus</i> Extract from Green Microwave-Assisted Eutectic Solvent Extraction as a Therapeutic Candidate Against Colon Cancer.

Antioxidants (Basel, Switzerland)·2025
Same author

The Disruption of <i>Cyp7b1</i> Controls IGFBP2 and Prediabetes Exerted Through Different Hydroxycholesterol Metabolites.

International journal of molecular sciences·2025
Same author

Antimicrobial Activity and Potential of Olive Leaf Extract as a Topical Agent to Combat <i>Staphylococcus aureus</i> and MRSA Strains: An In Vitro Evaluation.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Effect of Extra Virgin Olive Oil High in Bioactive Compounds on Atherosclerosis in Apoe-Deficient Mice.

Molecular nutrition & food research·2025
Same author

Chitosan Nanoparticles, a Novel Drug Delivery System to Transfer Squalene for Hepatocyte Stress Protection.

ACS omega·2025
Same author

Squalene in Nanoparticles Improves Antiproliferative Effect on Human Colon Carcinoma Cells Through Apoptosis by Disturbances in Redox Balance.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Apr 11, 2026

Quantification of Coenzyme A in Cells and Tissues
08:51

Quantification of Coenzyme A in Cells and Tissues

Published on: September 27, 2019

9.1K

PON1 and Mediterranean Diet.

José M Lou-Bonafonte1,2, Clara Gabás-Rivera3,4, María A Navarro5,6

  • 1Departamento de Farmacología y Fisiología, Facultad de Ciencias de la Salud y del Deporte, Instituto de Investigación Sanitaria de Aragón-Universidad de Zaragoza, Huesca, E-22002, Spain. mlou@unizar.es.

Nutrients
|May 30, 2015
PubMed
Summary

The Mediterranean diet, rich in extra virgin olive oil, nuts, fruits, and vegetables, protects against cardiovascular disease by enhancing Paraoxonase 1 (PON1) activity. This dietary pattern offers a protective effect on PON1, crucial for preventing atherosclerosis.

Keywords:
Mediterranean dietPON1fruitsnutraceuticalsnutsolive oilparaoxonase 1

More Related Videos

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

8.6K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.1K

Related Experiment Videos

Last Updated: Apr 11, 2026

Quantification of Coenzyme A in Cells and Tissues
08:51

Quantification of Coenzyme A in Cells and Tissues

Published on: September 27, 2019

9.1K
Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

8.6K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.1K

Area of Science:

  • Nutrition Science
  • Biochemistry
  • Cardiovascular Health

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide.
  • Paraoxonase 1 (PON1) is an enzyme linked to the development of atherosclerosis, a key factor in CVDs.
  • Dietary patterns significantly influence cardiovascular health and enzyme activity.

Purpose of the Study:

  • To systematically review the evidence on the Mediterranean diet's influence on Paraoxonase 1 (PON1) activity.
  • To identify specific Mediterranean diet components that modulate PON1.
  • To explore the potential of nutraceuticals and functional foods for enhancing PON1 activity.

Main Methods:

  • Systematic literature review of studies investigating the Mediterranean diet and its constituents.
  • Analysis of evidence regarding the impact on PON1 expression and activity.
  • Examination of genetic polymorphism influences on PON1 response.

Main Results:

  • The Mediterranean diet demonstrates a protective effect on PON1 activity, despite variations due to genetic polymorphisms.
  • Extra virgin olive oil significantly increases PON1 activity through various mechanisms, including oleic acid enrichment and minor component induction.
  • Other constituents like nuts, fruits, vegetables, and particularly pomegranate, also modulate PON1 activity.

Conclusions:

  • The Mediterranean diet beneficially modulates PON1 activity, contributing to cardiovascular protection.
  • Extra virgin olive oil and specific plant-derived compounds show significant potential for enhancing PON1.
  • Further research into nutraceuticals and functional foods targeting PON1 activity is warranted for CVD prevention.