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Progesterone can either increase or decrease weight gain and adiposity in ovariectomized Syrian hamsters.

A J Bhatia1, G N Wade

  • 1Department of Psychology, University of Massachusetts, Amherst 01003.

Physiology & Behavior
|August 1, 1989
PubMed
Summary
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Estradiol and progesterone interact to reduce body fat in hamsters, unlike in rats. This hormonal interaction in hamsters may explain why they decrease body fat during pregnancy.

Area of Science:

  • Endocrinology
  • Comparative Physiology
  • Reproductive Biology

Background:

  • Hormonal regulation of body composition is crucial.
  • Estradiol and progesterone play key roles in mammalian physiology.
  • Species-specific responses to hormones can impact metabolic adaptations.

Purpose of the Study:

  • To investigate the combined effects of estradiol and progesterone on weight gain, food intake, and carcass composition in Syrian hamsters.
  • To compare hamster responses to hormonal treatments with known rat responses.
  • To elucidate the role of these hormones in metabolic adaptations, particularly during pregnancy.

Main Methods:

  • Ovariectomized Syrian hamsters were treated with estradiol benzoate or progesterone alone, or in combination, via injections.

Related Experiment Videos

  • Physiological levels of 17 beta-estradiol and progesterone were administered using subcutaneous Silastic capsules.
  • Body weight, food intake, and carcass composition (adiposity) were assessed.

    • Main Results:

    • Estradiol benzoate alone decreased weight gain and adiposity in hamsters.
    • Progesterone alone increased weight gain and adiposity.
    • Concurrent administration of estradiol and progesterone resulted in a greater reduction in body fat than estradiol alone.
    • Estradiol's fat-reducing effects were exaggerated by progesterone in hamsters, contrasting with rats where progesterone reverses these effects.

    Conclusions:

    • Estradiol and progesterone interact synergistically to decrease body lipid stores in Syrian hamsters.
    • This species-specific interaction of progesterone with estradiol may explain differing body lipid strategies between hamsters and rats during pregnancy.
    • The findings highlight the complex, species-dependent hormonal regulation of energy balance and body composition.