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Vaccinations in paediatric rheumatology: an update on current developments

Noortje Groot1, Marloes W Heijstek, Nico M Wulffraat

  • 1Department of Pediatrics, Wilhemina Children's Hospital/University Medical Centre Utrecht (UMCU), PO-box 85090, 3508 AB, Utrecht, The Netherlands, n.groot@erasmusmc.nl.

Current Rheumatology Reports
|May 31, 2015
PubMed

Insights

Vaccinations are safe and immunogenic for children with rheumatic diseases. Despite potential waning antibody levels, especially with biologicals, booster vaccinations are recommended to ensure adequate protection.

Area of Science:

  • Rheumatology
  • Immunology
  • Pediatrics

Background:

  • European League Against Rheumatism (EULAR) published vaccination recommendations for children with rheumatic diseases in 2011.
  • The evidence base on vaccination safety and immunogenicity in this population has significantly expanded since 2011.

Purpose of the Study:

  • To provide an updated systematic literature review on the safety and immunogenicity of vaccines in pediatric patients with rheumatic diseases.
  • To summarize current evidence and strengthen the existing EULAR recommendations.

Main Methods:

  • Conducted a systematic literature search, identifying 21 new articles.
  • Included 27 articles from the 2011 review for a comprehensive analysis.

Main Results:

  • Vaccines are generally safe and immunogenic in children with rheumatic diseases.
  • Immunosuppressive drugs like glucocorticosteroids and methotrexate did not detrimentally affect vaccine immunogenicity.
  • Biologicals may lead to faster waning of antibody levels, but initial protection is typically adequate.

Conclusions:

  • Reduced persistence of immunological memory in children with rheumatic diseases necessitates booster vaccinations.
  • The updated evidence supports advocating for vaccinations in patients with rheumatic diseases.

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