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Updated: Apr 11, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.7K
Psoriasis.
Wolf-Henning Boehncke1, Michael P Schön2
1Department of Dermatology and Venereology, Geneva University Hospitals, Geneva, Switzerland; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Lancet (London, England)
|May 31, 2015
Summary
Psoriasis is a complex immune-mediated disease affecting skin and joints. Early diagnosis and comprehensive management are crucial for addressing its multifaceted challenges and improving patient outcomes.
Area of Science:
- Immunology
- Genetics
- Dermatology
- Rheumatology
Background:
- Psoriasis is a prevalent, chronic, immune-mediated genetic disease affecting skin and joints.
- It presents significant challenges including disfigurement, disability, and comorbidities.
- Effective management requires understanding immune system interplay and clinical diversity.
Purpose of the Study:
- To highlight the clinical diversity and associated comorbidities of psoriasis.
- To review recent advancements in psoriasis epidemiology, pathogenesis, and genetics.
- To raise awareness of psoriasis complexity and the need for comprehensive management.
Main Methods:
- Literature review and synthesis of current research on psoriasis.
- Analysis of epidemiological, pathogenetic, and genetic trends.
- Discussion of clinical manifestations and therapeutic approaches.
Main Results:
- Psoriasis exhibits significant clinical heterogeneity and is linked to various comorbidities.
- Advances in understanding immune mechanisms and genetic factors are shaping management.
- Current trends emphasize early diagnosis and multidisciplinary care.
Conclusions:
- Psoriasis is a complex, multifaceted disease requiring a comprehensive management strategy.
- State-of-the-art therapies offer improved outcomes for patients.
- Early diagnosis and integrated care are essential for addressing the full spectrum of psoriasis impacts.
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