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The Blood-brain Barrier

The Blood-brain Barrier

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Related Experiment Video

Updated: Apr 11, 2026

An In Vivo Blood-brain Barrier Permeability Assay in Mice Using Fluorescently Labeled Tracers

An In Vivo Blood-brain Barrier Permeability Assay in Mice Using Fluorescently Labeled Tracers

Published on: February 26, 2018

Blood-brain barrier permeability imaging using perfusion computed tomography.

Jernej Avsenik¹, Sotirios Bisdas², Katarina Surlan Popovic¹

¹Institute of Radiology, University Medical Centre Ljubljana, Slovenia.

Radiology and Oncology

|June 2, 2015

Summary

The blood-brain barrier (BBB) is crucial for brain health, regulating transport and signaling. Perfusion computed tomography offers an efficient method to evaluate BBB permeability in vivo, aiding in diagnosing stroke and brain tumors.

Keywords:

blood-brain barrier computed tomography perfusion CT permeability imaging

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Last Updated: Apr 11, 2026

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Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease

Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease

Published on: November 8, 2017

Area of Science:

Neuroscience
Medical Imaging
Vascular Biology

Background:

The blood-brain barrier (BBB) is a selective diffusion barrier formed by cerebral microvascular endothelial cells.
It plays vital roles in transport, signaling, and osmoregulation, interacting with surrounding neural cells.
BBB dysfunction is linked to various neurological conditions, including stroke, tumors, and neurodegenerative diseases.

Purpose of the Study:

To evaluate the utility of perfusion computed tomography (CT) for assessing blood-brain barrier permeability.
To highlight the diagnostic applications of this imaging technique in neurological conditions.

Main Methods:

In vivo evaluation of blood-brain barrier permeability.
Utilizing perfusion computed tomography with sequential tomographic image acquisition.
Intravenous administration of iodinated contrast material during imaging.

Main Results:

Perfusion CT enables efficient in vivo assessment of BBB permeability.
The technique involves dynamic imaging during contrast agent circulation.
Demonstrated effectiveness in evaluating BBB integrity.

Conclusions:

Perfusion computed tomography is an efficient diagnostic method for evaluating blood-brain barrier permeability in vivo.
Key clinical applications include the diagnosis of acute stroke and brain tumors.
This imaging modality provides valuable insights into BBB function in critical neurological diseases.