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Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
Published on: January 3, 2015
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Ovarian stem cells: From basic to clinical applications
Ozlem Bingol Ozakpinar1, Anne-Marie Maurer1, Derya Ozsavci1
1Ozlem Bingol Ozakpinar, Derya Ozsavci, Department of Biochemistry, School of Pharmacy, Marmara University, 34668 Istanbul, Turkey.
World Journal of Stem Cells
|June 2, 2015
Summary
Ovarian germline stem cells (GSCs) exist in adult mammals and can produce offspring. These cells may also be linked to ovarian cancer stem cells (CSCs), offering new therapeutic targets for infertility and cancer.
Area of Science:
- Reproductive Biology
- Stem Cell Biology
- Oncology
Background:
- Historically, a fixed oocyte reserve was believed to exist before birth.
- The discovery of ovarian germline stem cells (GSCs) in postnatal ovaries challenged this dogma.
- GSCs have been identified in mice and women, originating from the ovarian surface epithelium.
Purpose of the Study:
- To review the current understanding of ovarian GSCs in adult mammals.
- To explore the potential relationship between GSCs and ovarian cancer stem cells (CSCs).
- To highlight the therapeutic implications for infertility and ovarian cancer.
Main Methods:
- Literature review of studies on ovarian GSCs and CSCs.
- Analysis of marker expression and differentiation potential of GSCs.
- Examination of evidence linking GSCs to ovarian cancer development.
Main Results:
- Ovarian GSCs are present in adult mice and women, expressing GSC markers.
- Transplanted mouse GSCs can differentiate and lead to offspring.
- Evidence suggests a potential link between GSC dysfunction and ovarian CSCs.
Conclusions:
- Ovarian GSCs represent a significant finding in reproductive biology.
- The identification of GSCs and their potential role in ovarian cancer opens new avenues for research.
- Targeting GSCs and CSCs may offer novel therapeutic strategies for infertility and ovarian cancer.
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