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Published on: November 10, 2023
Follicular bronchiolitis: A rare cause of persistent atelectasis in children
Ângela Dias1, Joana Jardim1, Teresa Nunes1
1Unidade de Pneumologia Pediátrica, Serviço de Pediatria, Centro Hospitalar São João, Porto, Portugal.
Insights
Persistent atelectasis in children warrants investigation. This case highlights follicular bronchiolitis as a rare cause, successfully treated with corticosteroids after surgical intervention.
Area of Science:
- Pediatric Pulmonology
- Rare Respiratory Diseases
- Histopathology
Background:
- Persistent atelectasis in children necessitates identifying underlying causes.
- Follicular bronchiolitis is a rare pulmonary condition characterized by lymphoid follicles.
- Few pediatric cases of follicular bronchiolitis have been reported.
Purpose of the Study:
- To describe a pediatric case of persistent left upper lobe atelectasis.
- To identify follicular bronchiolitis as the cause of refractory respiratory symptoms.
- To discuss the management and outcome of this rare condition in a child.
Main Methods:
- Case report of a child with persistent atelectasis and respiratory symptoms.
- Surgical intervention with partial lobectomy.
- Histopathological examination of resected lung tissue.
- Clinical assessment and treatment response evaluation.
Main Results:
- Histopathology confirmed follicular bronchiolitis.
- The patient experienced initial improvement with inhaled corticosteroids, followed by relapse.
- Oral corticosteroid therapy led to a favorable clinical response.
- Surgical lobectomy was performed due to refractory symptoms.
Conclusions:
- Follicular bronchiolitis can present as persistent atelectasis and respiratory issues in children.
- Corticosteroid therapy, including oral forms, can be effective.
- Early diagnosis and appropriate treatment are crucial for favorable outcomes in rare pediatric lung diseases.
Abstract:
Although atelectasis is common in children, its persistence or refractoriness to treatment should lead prompt evaluation to identify causal mechanism. We describe the case of a child presenting in first year of life with persistent left upper lobe atelectasis, recurrent wheezing and respiratory infections refractory to medical therapy, submitted to partial lobectomy when he was 3 years old age. Histopathological examination revealed follicular bronchiolitis. Systemic underlying diseases were excluded. Clinical improvement was initially achieved using inhaled corticosteroids, but oral therapy was needed due to clinical relapse, with favorable response. Follicular bronchiolitis, a rare pulmonary primary lymphoid lesion, consists of numerous reactive lymphoid follicles in a peribonchiolar distribution. Its precise cause is unknown, particularly in children, in which few cases have been reported. Treatment usually includes steroids and prognosis is generally good.
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