Related Experiment Video
Updated: Apr 11, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
MiR-506: A Multitasker in Suppression of the Epithelial-to-Mesenchymal Transition
Yan Sun1, Delia Mezzanzanica2, Wei Zhang3
1Departments of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Abstract:
MiRNAs emerge as important regulators of epithelial-to-mesenchymal transition (EMT). The Best known EMT regulatory miRNAs are targeting the transcriptional repressors of E-cadherin (E-cad). We identified miR-506 as a key EMT inhibitor through directly targeting the E-cad transcriptional repressor, SNAI2. Our recent studies showed that miR-506 simultaneously suppresses vimentin and N-cad. Thus, miR-506 possesses a multitasking property in the suppression of EMT and metastasis and thus may represent a promising tool in cancer therapeutics.
Related Concept Videos
MicroRNAs
MicroRNAs
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

