[Psoriasis and comorbidity--literature review]

Area of Science:

• Dermatology
• Cardiology
• Metabolic Medicine

Background:

• Psoriasis is increasingly recognized as a systemic inflammatory condition, extending beyond cutaneous manifestations.
• Emerging research links psoriasis to a higher prevalence of metabolic disorders, including obesity, diabetes, and cardiovascular diseases.
• The concept of the 'psoriatic march' highlights psoriasis as a potential risk factor for developing these comorbidities.

Purpose of the Study:

• To elucidate the systemic implications of psoriasis, particularly its association with metabolic syndrome and cardiovascular diseases.
• To underscore the importance of recognizing psoriasis as a multifaceted disease with significant systemic impact.
• To review the epidemiological evidence supporting the link between severe psoriasis and metabolic and cardiovascular comorbidities.

Main Methods:

• Review of epidemiological studies and scientific literature on psoriasis pathogenesis.
• Analysis of the co-occurrence of psoriasis with metabolic syndrome components (insulin resistance, dyslipidemia, obesity, hypertension).
• Examination of the relationship between psoriasis and cardiovascular system diseases.

Main Results:

• Frequent coexistence of metabolic syndrome in patients with severe psoriasis.
• Psoriasis is associated with increased risk of obesity, diabetes, and cardiovascular diseases.
• Coexistence of autoimmune disorders, cancers, and psychological distress (depression, low self-esteem) observed in psoriasis patients.

Conclusions:

• Psoriasis is a systemic disease with significant metabolic and cardiovascular implications.
• The 'psoriatic march' emphasizes the link between severe psoriasis and cardiovascular disease development.
• Comprehensive management of psoriasis should address its systemic comorbidities and psychological impact.