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Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

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Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
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Osmoregulation in Fishes02:32

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When cells are placed in a hypotonic (low-salt) fluid, they can swell and burst. Meanwhile, cells in a hypertonic solution—with a higher salt concentration—can shrivel and die. How do fish cells avoid these gruesome fates in hypotonic freshwater or hypertonic seawater environments?
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Positive and Negative Feedback Loops01:18

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Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
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Regulation of Metabolism01:19

Regulation of Metabolism

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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The human body predominantly expels water through the urinary system. On average, an individual generates around 1.5 liters of urine each day. This amount can fluctuate based on how well a person is hydrated, but a critical minimum quantity of urine must be produced to ensure the body's proper functioning. Daily, the kidneys remove 600 to 1200 milliosmoles of dissolved substances, effectively excreting excess minerals and water-soluble toxins such as creatinine, urea, and uric acid from the...
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Tonicity in Animals00:59

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The tonicity of a solution determines if a cell gains or loses water in that solution. The tonicity depends on the permeability of the cell membrane for different solutes and the concentration of nonpenetrating solutes in the solution within and outside of the cell. If a semipermeable membrane hinders the passage of some solutes but allows water to follow its concentration gradient, water moves from the side with low osmolarity (i.e., less solute) to the side with higher osmolarity (i.e.,...
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Updated: Apr 11, 2026

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
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Bioregulation.

Arthur B Pardee1

  • 1Dana Farber Cancer Institute, Boston, Massachussetts.

Journal of Cellular Physiology
|June 3, 2015
PubMed
Summary
This summary is machine-generated.

20th-century molecular biology advances set the stage for future discoveries in bioregulation. Scientists can now translate basic science findings into clinical applications for diseases like cancer and heart disease.

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Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Significant progress in genetics and biochemistry during the 20th century led to a molecular understanding of macromolecule functions.
  • This foundation is crucial for exploring complex biological processes.

Purpose of the Study:

  • To highlight the potential of future discoveries in bioregulation.
  • To connect basic science advancements to clinical applications for various diseases.

Main Methods:

  • Review of historical progress in molecular biology.
  • Identification of current research frontiers in bioregulation.

Main Results:

  • Bioregulation research holds promise for understanding cell development and evolution.
  • Defective bioregulation is implicated in heart disease and neurological disorders.
  • The fight against cancer requires continued scientific innovation.

Conclusions:

  • The current generation of scientists is positioned to translate recent basic science discoveries into clinical applications.
  • Further research into bioregulation is essential for addressing significant health challenges.