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Updated: Apr 11, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Drug therapy in headache.

Mark W Weatherall1

  • 1Princess Margaret Migraine Clinic, Charing Cross Hospital, London, UK mweatherall@nhs.net.

Clinical Medicine (London, England)
|June 3, 2015
PubMed
Summary
This summary is machine-generated.

This review covers drug therapies for common adult headaches, including tension-type headache, migraine, and cluster headache. It details acute, preventive, and emergency parenteral treatments based on clinical evidence.

Keywords:
CGRPMigraineanalgesicscluster headacheprophylaxistension-type headachetriptans

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Headaches are a common patient complaint encountered by physicians.
  • Primary headache disorders, such as tension-type headache, migraine, and cluster headache, are prevalent and can be disabling.

Purpose of the Study:

  • To review the principles of drug therapy for adult headaches.
  • To focus on the three most common primary headache disorders.
  • To present clinical evidence for acute and preventive treatment options.

Main Methods:

  • Review of clinical evidence for drug therapies in headache management.
  • Focus on tension-type headache, migraine, and cluster headache.
  • Inclusion of emergency parenteral treatment options for refractory cases.

Main Results:

  • Provides a comprehensive overview of drug therapy principles for common headaches.
  • Details evidence-based choices for acute and preventive treatments.
  • Outlines emergency parenteral treatment options for severe migraine and cluster headache.

Conclusions:

  • Physicians can utilize this review to make informed drug therapy choices for adult patients with common primary headaches.
  • The paper serves as a guide for managing tension-type headache, migraine, and cluster headache effectively.
  • Evidence-based treatment strategies for both routine and emergency care are presented.