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Nebulized medication is not associated with nosocomial infections. A pilot study
David Vinuesa, Violeta Ramos, Alejandro Peña
1Jorge Parra-Ruiz, Servicio de Enfermedades Infecciosas - Hospital Universitario San Cecilio Avda Dr. Oloriz 16. 18012 Granada, Spain. jordi@ugr.es.
Introduction:
Nebulized devices are commonly used in the treatment of respiratory infection, and other respiratory diseases. It has been reported nosocomial infections in cystic fibrosis patients as a result of the use of contaminated devices. However, little is known about nosocomial infections secondary to aerosolized therapy in COPD patients admitted for acute exacerbation.
Methods:
Thirty consecutive patients (13 males) were included. All of them received aerosolized medication. Each patient used their own facemask and nebulizer cup, which were stored in the room after its use. Samples from nebulizer cups were obtained on days 0, 4 and 7. In addition, sputum samples were obtained on day 0 (prior to any nebulization) and on day 7, and cultivated in enriched media.
Results:
Only nine nebulizer cups had positive microbiological cultures. Coagulase negative staphylococci (CoNS) were isolated in all cases. Sputum samples could be obtained in 27 patients. None grew CoNS after 7 days of aerosolized therapy. Gram-negative non-fermenting bacilli were isolated in three patients without concomitant grown in nebulizer cups.
Conclusions:
We did not find any nosocomial infection related to aerosolize medications in COPD patients admitted for acute exacerbation.
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