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[Biochemical changes in skeletal muscles after chronic indirect stimulation]
Zeitschrift Fur Medizinische Laboratoriumsdiagnostik
|January 1, 1989
Summary
Chronic electrical stimulation transforms fast-twitch skeletal muscle into a fatigue-resistant, slow-twitch type. This finding supports skeletal muscle
Area of Science:
- Biomedical Engineering
- Muscle Physiology
- Cardiac Surgery
Context:
- Skeletal muscle's adaptive capacity presents opportunities for cardiac support.
- Investigating chronic electrical stimulation's effects on skeletal muscle.
- Assessing enzyme activity and energy status in stimulated muscle.
Purpose:
- To investigate skeletal muscle's transformation potential under chronic electrical stimulation.
- To determine if stimulated skeletal muscle can be adapted for hemodynamic work.
- To evaluate changes in key enzymes and energy metabolites.
Summary:
- Adult sheep's psoas muscles were chronically stimulated at 15 Hz for 5 weeks.
- Enzyme activities (hexokinase, LDH, MDH, CK, ChAT) and adenine nucleotides were measured.
- Stimulation induced a fast-twitch to slow-twitch muscle transformation, reducing fatigue.
Impact:
- Demonstrates skeletal muscle's plasticity for functional adaptation.
- Highlights potential for skeletal muscle as a myocardial substitute.
- Suggests feasibility of engineered cardiac support using skeletal muscle.