Related Experiment Video
Updated: Apr 11, 2026

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
PEGylated IFNβ-1a in the treatment of multiple sclerosis
Umair Tahir Khan1, Radu Tanasescu, Cris S Constantinescu
1University of Nottingham, Queen's Medical Centre, Division of Clinical Neuroscience, Clinical Neurology Research Group , Nottingham, South Block C Floor, Nottingham NG7 2UH , UK.
Introduction:
Multiple sclerosis (MS) is a chronic immune-mediated disease of the CNS characterized in most cases by a relapsing and remitting disease course, often followed by a progressive course. There are many available injectable therapies for the relapsing-remitting form of MS (RRMS); however, efficacy can be affected by poor adherence and compliance, and an increased frequency of side effects as a result of frequent injections is seen.
Areas Covered:
This review focuses on the use of subcutaneous PEGylated IFNβ-1a (PEGIFN β-1a) in RRMS. The pharmacological data in addition to clinical safety and tolerability are analyzed. The clinical efficacy is assessed by evaluating results of various end points used in the ADVANCE Phase III study and the differences between treatment groups over 2 years.
Expert Opinion:
We discuss the significance of the ADVANCE trial results and how the results compare to other products on the market. Due to a lack of head-to-head comparison of PEGIFN β-1a with other types of drugs for RRMS, it is difficult to draw conclusion about the superiority of the drug. We also discuss whether the results can be applied to patients with more severe forms of the disease. Overall, PEGIFN β-1a is a promising addition to the repertoire of emerging drugs for the treatment of RRMS.
More Related Videos
10:00High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
13:41Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...