Related Experiment Video
Updated: Apr 11, 2026
08:59
Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
Published on: July 16, 2021
3.3K
[Advance in genetic research on multiple system atrophy]
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R.China. jianghong73868@126.com.
Summary
Genetic factors may contribute to Multiple System Atrophy (MSA), a progressive neurodegenerative disorder. Emerging research highlights the role of specific genetic variants in MSA pathogenesis, challenging its previously sporadic nature.
Area of Science:
- Neurodegenerative diseases
- Neuropathology
- Genetics
Context:
- Multiple System Atrophy (MSA) is characterized by glial cytoplasmic inclusions.
- MSA has historically been viewed as a sporadic condition.
- Recent findings suggest a potential genetic basis for MSA.
Purpose:
- To review the emerging evidence for genetic factors in Multiple System Atrophy (MSA).
- To discuss the role of genetic variants in MSA pathogenesis.
Summary:
- While typically considered sporadic, Multiple System Atrophy (MSA) shows increasing evidence of genetic influence.
- Familial cases and identified risk-conferring genetic variants suggest a significant role for genetics.
- Glial cytoplasmic inclusions remain the neuropathologic hallmark of this progressive neurodegenerative disorder.
Impact:
- This review highlights the importance of genetic research in understanding MSA.
- Understanding genetic contributions may lead to new diagnostic or therapeutic strategies for MSA.
- Shifts the paradigm of MSA etiology towards a multifactorial model involving genetic predisposition.
Related Concept Videos
01:15Parkinson's Disease: Overview
2.4K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.4K
02:59Animal Mitochondrial Genetics
10.1K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
10.1K
01:29Pharmacogenomics: Identification of New Drug Targets
91
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
91