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Age-determined changes in the effects of a newly synthetized cholinesterase inhibitor on exploratory behavior, memory
C Castellano1, V V Petkov, R Kehayov
1Institute of Psychobiology and Psychopharmacology, CNR, Rome, Italy.
Acta Physiologica Et Pharmacologica Bulgarica
|January 1, 1989
Abstract:
The newly synthetized cholinesterase inhibitor C-8 (a structural analogue of physostigmine) at a dose of 4 mg.kg-1 exerted no inhibitory effect on the spontaneous locomotor activity in 2-, 10- and 22-month old male Wistar rats. Upon open field test, C-8 facilitated the process of habituation in the rats of all three groups. In a passive avoidance situation (step-down and step-through) C-8 had a favorable effect on the memory of 22-month old rats mainly. C-8 inhibited the cholinesterase activity in the striatum of 2-month old rats by 29%, in 10-month old rats by 73%, and in 22-month old rats by 30%.