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Updated: Apr 11, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

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Asymmetric conformational maturation of HIV-1 reverse transcriptase

Xunhai Zheng1, Lalith Perera1, Geoffrey A Mueller1

  • 1Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, United States.

Elife
|June 4, 2015
PubMed
Summary

HIV-1 reverse transcriptase (RT) uses a flexible domain that changes shape for different functions. This study reveals the complex folding and maturation process of RT, crucial for its activity.

Keywords:
DNA repairHIV-1 reverse transcriptaseNMRbiophysicshumanmousestructural biologyviruses

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